I'm using the 161-in-1 in my 4-slot in slot1 with no issues. However, it's my second one. Something happened to the original one I bought. So I ended up buying another one. It would have cost almost as much to send the cart back to them for a replacement as it was to just buy a new one. That cart is what led me to this site though, so I'm not too upset about it.
Anyway, the cart seems to work when played.