I finally saw this. Didn't dislike it as much as Number Six, but I agree with most of his points.
Like Prometheus, this was full of promise, it looked right, it had the right tone, and then... it just didn't deliver. It didn't go full-retard like Prometheus did, it more just fizzled.
They most enjoyable things for me were the look of it, and the background details. The huge Atari logo was an obvious choice, but the smaller "Pan-Am" building in the background was nice too - clearly an alternate universe. Gosling's flying car was a Peugeot of all things too...
In the original, I remember thinking that Replicants were supposed to be kind of like Androids. Maybe with some organic bits, but still at least somewhat machine-like on the inside. Maybe I was wrong about that though.
In this one though, Jared Leto has invented... humans? Um... we've known how to make more humans for quite some time... I mean these are born as adults, and can't reproduce, but other than that they're just people? Also, they claim there is this desperate need for more colonists, but at the same time the Earth appears to be over-populated, so...
The "twist" ending didn't make a hell of a lot of sense to me either - was the daughter placed in the "bubble" for her protection from the world, or did she really have a compromised immune system? That seems like the sort of thing that would have been engineered out, if these are either androids or designer people...
It was long and it was slow. I didn't hate it but man, it sure wasn't great.